8/25/2023 0 Comments Brain test 2 level 10![]() Under the action of dobutamine, an increase in cardiac output (CO), heart rate (HR), and blood pressure occurs, with incidences of tachycardia, arrhythmia, and hypertension. Thus, attention should be paid to blood pressure, BMI, and cerebrovascular morphology of patients undergoing dobutamine stress echocardiography or those receiving intensive care or anesthesia.ĭobutamine is a sympathomimetic drug widely used in clinical practice for cardiac stress testing for the noninvasive detection of coronary artery disease it is also used in intensive care and anesthesia to manipulate cardiovascular parameters. Individuals with a high BMI and low SBP during the dobutamine stress test are more likely to have a stress-induced CBF decrease. Conclusionsĭobutamine-induced stress significantly decreased CBF in the frontal lobe anterior circulation. Furthermore, compared with the CBF in the resting state, that in the stress state was decreased in the anterior circulation, mainly in the frontal lobe (voxel level P < 0.001, pixel level P < 0.05). Compared to the CBF in the resting state, the CBF values exhibited significantly lower CBF levels in both grey matter and white matter. ![]() ![]() HR, RR, systolic (SBP), and diastolic blood pressure (DBP) significantly increased after dobutamine infusion. Binary logistic regression was used to test for the independent determinants of CBF changes. The anatomic features of the circle of Willis and the basilar artery (BA) diameter were assessed on MRA images by two radiologists with extensive neuroimaging experience. Electrocardiogram, heart rate (HR), respiration rate (RR), blood pressure, and blood oxygen were simultaneously recorded before and during dobutamine injection and during recovery (not during MRI). Additionally, cerebrovascular morphology was obtained based on 3D-time-off-light (3D-TOF) magnetic resonance angiography (MRA). Methodsįorty-eight healthy volunteers without cardiovascular or cerebrovascular disease underwent MRI to obtain cerebral blood flow (CBF) maps using 3D pseudocontinuous arterial spin labeling before and during the dobutamine stress test. Therefore, we investigated the effects of dobutamine on cerebral hemodynamics. Cerebral microcirculation plays an important role in ensuring adequate oxygen transport. It is unclear whether dobutamine, commonly used clinically in echocardiography and short-term congestive heart failure treatment for promoting increased myocardial contractility, affects brain microcirculatory behavior.
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